Curcumin, a substance in turmeric, combined with an omega-3 fat may potentially delay or prevent the onset of type-2 diabetes, according to researchers.
Health scientists from the University of Newcastle's Nutraceuticals Research Group, led by Professor Manohar Garg, are seeking 80 recruits for a new clinical study to find out whether the Indian spice combined with an omega-3 fat can delay the onset of type 2 diabetes or prevent it altogether.
"The root cause of type 2 diabetes is systemic inflammation, which impacts insulin secretion and function," said Garg. "We want to nip the inflammation in the bud," he said. "This study will use two bioactive compounds that we find in food – curcumin and omega-3 fat. Both are very important anti-inflammatory agents," Garg said.
Curcumin, derived from turmeric, is part of the ginger family and commonly used for food colouration. Its healing properties are well known in India.
"Turmeric has been used for centuries to promote healing of bruises, sprains, wounds and inflammation," he said. "Nowadays in India the level of curcumin (turmeric) intake has dropped considerably as people switch to Westernised fast foods, and it parallels with a significant rise in type 2 diabetes cases. In fact the disease is now an epidemic in India and may soon be the number one health burden," said Garg.
The randomised control trial will test both compounds, with the recruitment group being segregated into four. One will get curcumin only, the second will get omega-3 fat only, the third will receive both, and the fourth will serve as a control group.
The capsules contain 200 milligrammes of curcumin and one gramme of omega-3 fat respectively. People who are prone to develop diabetes because of impaired glucose tolerance or impaired fasting glucose, and who are aged between 30 and 70, may be eligible.
"The anti-inflammatory mechanisms surrounding curcumin and omega-3 fats are different, so we want to test if they complement each other and have treatment synergies beyond their individual effects," Garg said."Our thinking is that the combination is safe, free of any side-effects and may prove to be as effective as drugs used for management of diabetes," he added.
