Real Madrid defender Pepe has been ruled out for up to four weeks with a torn calf muscle, the Spanish club said on their website on Friday.
The Portugal centre back suffered the injury during their 2-0 King's Cup defeat away to Levante on Thursday, when they progressed to a quarter-final meeting with city rivals Atletico Madrid, 8-2 on aggregate.
Pepe will miss both legs of the Cup tie, which are scheduled to be played over the next two weeks, and Sunday's high-profile La Liga clash with third-placed Villarreal at the Bernabeu.
