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New ‘most mutated COVID-19 variant’ found in South Africa
The variant being called C.1.2 has been found to be more mutated in comparison to any other known variant of COVID-19.
Updated : Aug 30, 2021, 10:06 AM IST | Edited by : Chitresh Sehgal
 "New ‘most mutated COVID-19 variant’ found in South Africa")
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South Africa: A new COVID-19 variant, C.1.2, detected in South Africa and several other countries, has put global health experts on alarm.
As per a new study that is preprint and awaits peer review, the C.1.2 variant may be more infectious and have the ability to evade COVID-19 vaccines currently available.
The study, conducted by South Africa's National Institute for Communicable Diseases and the KwaZulu-Natal Research Innovation and Sequencing Platform, showed that C.1.2, first detected in May 2021, had evolved from C.1 strain which was detected last in January.
The scientists discovered that C.1.2 has “mutated substantially” in comparison to C.1. The new strain also has more mutations from the original COVID-19 strain that emerged from Wuhan, China, compared to all other Variants of Concern (VOC) or Variants of Interest (VOI) detected across the world so far.
Not just South Africa, the presence of C.1.2 has also been confirmed in other countries like China, England, New Zealand, Portugal, Switzerland, the Democratic Republic of the Congo and Mauritius.
Furthermore, the study says that the mutation rate (41.8 mutations per year) of C.1.2 variant is almost twice as fast as the global mutation rate shown currently by other variants.
The scientists said that this faster rate of mutation for a short duration is consistent with the evolution of Alpha, Beta and Gamma variants. This could mean that a single evolution event, which was followed by a spike in COVID-19 caseload, was behind the faster rate of mutation.
Escaping antibodies
The C.1.2 has also shown the N440K and Y449H mutations, which are linked to the ability to evade some types of antibodies produced by COVID-19 vaccines. The scientists believe these mutations likely mean that C.1.2 can escape vaccines or antibodies in people developed from Alpha or Beta variant infections.
On whether C.1.2 is more dangerous than the currently dominant Delta variant, scientists say more research work is needed to confirm.
